2 μg) Teriparatide group (56.5 μg) Item Time Median Max Min Median Max Min Median Max Min Intact-PTH (pg/mL) Baseline 33.5 53.0 24.0 34.5 50.0 28.0 42.5 52.0 32.0 2 to 24 h 43.0 75.0 22.0 34.5 66.0 17.0 35.0 65.0 18.0 4 to 15 days 46.5 81.0 27.0 45.5 64.0 25.0 49.0 109.0 26.0 1,25(OH)2D (pg/mL) Baseline 56.5 79.0 33.0 53.0 79.0 34.0 63.5 75.0 40.0 2 to 24 h 54.0 93.0 26.0 67.5 118.0 37.0 70.5 136.0 33.0 4 to 15 days 61.0 95.0 29.0 56.0 99.0 21.0 54.0 94.0 18.0 Serum osteocalcin (ng/mL) Baseline 9.6 13.4 7.3 8.8 12.5 learn more 5.4 9.2 15.8 4.2 2 to 24 h 8.6 13.6 5.5 7.6 12.7 4.6 7.4 16.7 3.2 4 to 15 days 8.6 12.4 4.8 8.1 12.2 4.6 7.9 17.9 4.3 Serum P1NP (ng/mL)
Baseline 62.9 90.2 39.8 52.8 81.3 32.8 59.5 109.0 21.1 2 to 24 h 53.5 91.4 36.0 47.4 77.4 28.0 49.1 101.0 13.0 4 to 15 days 51.6 89.4 31.0 53.5 80.2 30.7 56.9 118.0 18.3 Serum NTX (nM BCE/L) Baseline 12.7 22.8 11.1 13.9 19.0 9.5 13.1 19.6 10.9 2 to 24 h 11.8 24.5 7.4 14.2 21.7 9.2 13.8 27.7 7.2 4 to 15 days 13.1 22.7 8.3 13.2 20.4 7.2 10.7 20.6 7.5 Urinary CTX (μg/mmol) Baseline 358.0 798.0 275.0 376.5 746.0 268.0 487.0 736.0 272.0 2 to 24 h 301.0 679.0 92.7 402.5 958.0 192.0 508.5 1190.0 238.0 4 to 15 days 374.0 722.0 202.0 351.0 655.0 106.0 351.0 972.0
142.0 PTH parathyroid hormone, P1NP procollagen type I N-terminal propeptide, NTX cross-linked N-telopeptide Captisol of type I collagen, CTX cross-linked C-telopeptide of type I collagen Changes in bone formation markers Percent change from baseline and percent changes subtracted by the corresponding placebo values were calculated for serum P1NP and osteocalcin. Oxalosuccinic acid In the placebo group, serum levels of
P1NP and osteocalcin were increased after injection followed by a gradual decrease to ~15 % below baseline (Fig. 4a–d). There were no remarkable Selleck RepSox dose-related differences in P1NP changes. Serum osteocalcin levels followed a similar trend including a dose-dependent response. However, the late-phase increase was not as obvious (+10 %).