We produced an environmental and occupational publicity questionnaire precise to these ANCs making use of their respective bodily, chemical, toxicologi cal, and environmental fate and transport information as well as informa tion on their use in commerce and business products. This fundamental info exact to every ANC guided us in developing an hop over to here publicity matrix informing the analyst of exposure media and pathway of concern for each ANC. Moreover, a weighted scoring method was produced, which takes publicity frequency and publicity duration into consideration then enables development of relative exposure score distibutions for a offered pathway, a given exposure medium, and/or a offered ANC. We also have the skill to separately analyze the exposure scores pertaining to each and every question while in the questionnaire. We have now obtained information on about 200 instances from brain tumor clinics and 180 buddy and 180 sibling controls.
Variability from the publicity scores witnessed within the preliminary outcomes suggest that this exposure assessment methodology is useful and useful in cancer epidemiological investigations. Additionally, preliminary information indicate that exposure to selected ANCs inside the breathing zone might improve Tubastatin A the risk of brain tumors. Distinct environmental expo sure situations linked to greater risk can also be identified. These data, combined with biomarkers of publicity, will ultimately offer a robust data set for understanding publicity to ANCs externally and internally and important publicity characterization data to improved recognize the etiology of brain cancer. EP 03. Publicity RECONSTRUCTION Technique TO EXAMINE GLIOBLASTOMA MULTIFORME Threat Amongst A COHORT OF JET ENGINE MANUFACTURING Workers N. Esmen,1 S. Lacey,1 K. Kennedy,1 and R. Hancock,one G. Marsh,two J.
Buchanich,two F. Lieberman,two A. Youk,two and Z. Bornemann2, 1University of Illinois at Chicago, Chicago, IL, USA, 2University of Pittsburgh, Pittsburgh, PA, USA

An exposure reconstruction is under way at the University of Illinois at Chicago as part of a collaborative effort with the University of Pitts burgh on their occupational epidemiology study of glioblastoma multiforme mortality amongst a cohort of jet engine manufacturing staff. The 7 year study began in 2002, when concern over a suspected cluster of brain cancer arose in one of a companys several manufactur ing plants. The primary goal of the UPitt study is to determine whether the cohort has an increased chance of mortality from GBM, and the goal of the UIC study is to examine possible occupational risks for this outcome. Exposures will be reconstructed for staff employed at one or more of eight plants from 1952, when the plant where the concern arose opened, through 2001, the designated cohort end date.