We found that, overall, hermaphrodites from populations with males tended to be more female than those from populations lacking males. Importantly, hermaphrodites’ investment in pollen
and Bcl-2 inhibitor seed production was more plastic when they came from populations with males than without them, reducing their pollen production at low resource availability and increasing their seed production at high resource availability. These results are consistent with the hypothesis that plasticity in sex allocation is enhanced in hermaphrodites that have likely been exposed to variation in mating opportunities due to fluctuations in the frequency of co-occurring males.”
“A simple, rapid, and sensitive method based on liquid chromatography-tandem mass spectrometry for the quantitative determination of simvastatin in human plasma was developed and validated. After a simple extraction with methyl tert-butyl ether, the analyte and internal standard (lovastatin) were analyzed using reverse-phase
liquid chromatography, on a Kinetex C-18 column (100 x 4.6 mm, 2.6 CP-456773 datasheet mu m) using acetonitrile: ammonium acetate (2 mM + 0.025 % formic acid) (70: 30, v/v) as a mobile phase in a run time of 3.5 min. Detection was carried out using electrospray positive ionization mass spectrometry in the multiple-reaction monitoring mode. The method was linear over 0.04-40.0 ng/mL concentration SRT2104 in vivo range. The mean extraction recovery of simvastatin was 82% (RSD within 15%). Intraday and interday precisions (as relative standard deviation) were all smaller than = 8,7% with accuracy (as relative error) of +/- 8%. This rapid and reliable method was successfully applied for a bioequivalence study of 40 mg of simvastatin orally disintegrating tablets in 44 healthy volunteers, showing that this method is suitable for the quantification of simvastatin in human plasma samples for pharmacokinetics and bioequivalence studies.”
“Context. – The cortico-basal syndrome (CBS), a complex clinical neurodegenerative disorder,
may have multiple aetiologies including corticobasal degeneration (CBD) and Alzheimer’s disease (AD). The aim of this study was to explore the brain perfusion profile in CBS patients according to the biological profile of CFS biomarkers (BM). Materials and methods. – Fifteen patients fulfilling clinical criteria of CBS underwent a brain perfusion scintigraphy with Tc-99m-ECD and a lumbar punction to determine the biochemical profile of CSF biomarkers (BM). Several groups were compared with SPM8 software: 1) 5 patients with SCB and with an AD CSF profile (CBS-AD); 2) 10 patients with CBS and not having an AD CSF profile (SCB-nonAD); 3) 24 healthy controls (Wit-N); 4) 24 typical amnestic (AD). Results.