There were a number of replicated findings, such as the presence of abnormal movements, higher degrees of psychopathology especially hallucinations, a greater degree of chronicity, that were potential indicators of dopamine supersensitivity in both studies. In addition, in both studies, the AIM +ve patients #Erlotinib mw randurls[1|1|,|CHEM1|]# were unlikely to have their medication increased. It could Inhibitors,research,lifescience,medical be that this

reflects an understanding by the prescribing clinician that these individuals had noticeable side effects and reflects an attempt not to exacerbate them by increasing the dose of antipsychotic. In both studies patients with relapses associated with a life event subsequently experienced a more benign course of their illness. Previous research has also found that patients with life events prior to psychotic relapse were more likely to score zero on the AIM scale, more likely to experience complete symptom remission between episodes of illness and have less need for antipsychotic Inhibitors,research,lifescience,medical maintenance medication [Van Os et al. 1994]. In the present study, the AIM -ve patients were more likely to have their medication increased than the AIM -ve patients in the previous study, and this almost Inhibitors,research,lifescience,medical reached statistical significance (p = 0.06 two-tailed). Furthermore, the AIM +ve group were prescribed lower doses that the AIM -ve group, which was not found previously [Fallon and Dursun, 2011]. However, this may be because a significant

proportion of those with Inhibitors,research,lifescience,medical abnormal movements were prescribed oral atypical antipsychotic medications. When these medications are converted to chlorpromazine equivalent doses, they are prescribed in smaller doses than were the doses of typical antipsychotics historically. For example, olanzapine 5 mg equates to 100 mg of chlorpromazine [Woods, 2003], therefore, the maximum daily dose of olanzapine currently prescribed on license in the UK (20 mg) equates to 400 mg of chlorpromazine per day. The fifth aim was to develop the diagnostic criteria for supersensitivity Inhibitors,research,lifescience,medical psychosis and two main differences to Chouinard’s criteria were found in this study [Chouinard, 1990]. Firstly, withdrawal of medication

was not present Thiamine-diphosphate kinase in the sample, which is unsurprising as this was a study into patients compliant with stable doses of medication. Secondly, antipsychotics were not prescribed in high doses and evidence of tolerance was not present. This can be explained by the changes in prescribing atterns as atypical antipsychotics are now the redominant form of antipsychotic prescribed. It has been argued that the newer atypical medications are more tolerable as they produce fewer side effects [Voruganti et al. 2000]. However, in this study, patients prescribed atypical antipsychotics were as likely as patients prescribed typical antipsychotics to display AIMs, and risperidone has previously been found to induce extrapyramidal side effects comparable to haloperidol [Knable et al. 1997].