The Mesdaghi et al.27 study showed a 25% prevalence rate of sensitivity to DP, and Dowaisan et al.28 and Seedat et al.26 reported sensitivity of 32.4% and 34% to DF among the same type of patients. In allergic rhinitis patients, a 32.8% rate of positive SPT to Alternaria Erlotinib price alternata was reported in the Iranian city of Mashhad,29 which chimes in with our study Inhibitors,research,lifescience,medical (28%). Cockroach sensitivity among all the patients in our study was estimated at 18%. Approximately similar results were reported in two of Iran’s Arab neighboring countries: 19.2% in the city of Riyadh (139 patients with airway allergy)30

and 22.7% in Oman (689 patients).31 In contrast, a prevalence rate of 2.8% sensitivity to cockroaches was reported Inhibitors,research,lifescience,medical from Turkey;32 this finding is different

from the rate reported in our country (2.8% versus 18%). These discrepancies require further research. In our patients with allergic rhinitis, 8.4% had a positive SPT to feather mix. This finding is in accordance with studies conducted in Iran27 and South Africa,26 whose results revealed 9.5% and 10% prevalence rates of sensitivity to feather allergen. A positive SPT to cow’s milk was seen in 21.7% of our patients. This finding is in agreement Inhibitors,research,lifescience,medical with that (21.46%) of the Khazaei et al.33study, which was done in the Iranian city of Zahedan. In this study, walnuts were a common food allergen with a prevalence rate of 17.1%, which is similar to the rate reported by another study34 in Iran. Such Inhibitors,research,lifescience,medical similarity regarding a positive SPT to hazelnuts is seen between our study (14.9%) and another study33 carried out in Iran (15.32%). It is probable that the consumption of nuts is high in Iran. In concordance with some previous studies,35-37 sensitivity to allergens in our patients with a positive family history (59.3%) was higher than that in those without a family history. Conclusion Determination of the most common allergens Inhibitors,research,lifescience,medical and the relationship between the results of the SPT and

allergic diseases in each area plays an important role in the diagnosis and mafosfamide management of allergic disorders and possibility of performing immunotherapy. In this study, tree mix, Alternaria alternate, and weed mix comprised the most common aeroallergens and milk, eggs, and wheat constituted the most common food allergens. In light of the findings of the present study, it can be concluded that appropriate preventive strategies can decrease the cost and morbidity of therapeutic measures. Conflict of Interest: None declared.
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system. The etiology of MS is complicated, and both environmental and genetic factors play important roles in the pathogenesis of the disease.1,2 Several genes have been investigated, but studies on association with human leukocyte antigen (HLA) have been the most consistent.