The best cut-off of number of pharmacies and number of prescribers also had to have a sufficient proportion of subjects to provide a useful marker of unsanctioned use. Once the definition was selected, we identified subjects who met the definition, i.e. subjects with at least one event of overlapping prescriptions written

by two or more prescribers and filled at three or more pharmacies. The index MEK inhibitor or qualifying event did not necessarily occur during the episode with the highest number of overlapping prescriptions. We then assessed how soon the shopping episode was observed during follow-up of a given subject (i.e. median time from index date to first shopping episode), the total number of events across all subjects according to age category, sex, and prior exposure (naïve or experienced), and the concentration of shopping (extent to which a relatively small proportion of shoppers accounted for a relatively large proportion of shopping episodes). Each time there was a new dispensing, the definition of shopping behavior was applied and, if the criteria

were met, learn more a new shopping episode was counted. To make sure that the subjects dispensed prescribed asthma medication had a similar age distribution to the subjects dispensed ADHD medications, the asthma subjects were frequency-matched to the ADHD subjects by single year of birth. This study used completely anonymized data and did not this website involve patient contact. The New England Institutional Review Board determined that this was not human-subject research. 3 Results A total of 4,402,464 subjects dispensed ADHD medications and 6,128,025 subjects dispensed asthma medications were included in the analysis. The age distribution (mean ± SD) of the subjects was similar in the two cohorts—24.1 ± 16.2 years of age in the ADHD medication cohort and 24.2 ± 16.8 in the asthma medication Nutlin-3 datasheet cohort, as

would be expected from the age matching. In the ADHD medication cohort, 43.9 % were female, and in the asthma medication cohort, 55.6 % were female. The distribution of pharmacies and prescribers visited by subjects was markedly different in subjects who received ADHD drugs compared with those who received asthma drugs. Overlapping prescriptions written by two or more prescribers and dispensed at two or more pharmacies were approximately twofold more frequent in the ADHD medication cohort than in the asthma medication cohort, and occurred in 198,923 subjects in the ADHD medication cohort (4.5 %) and in 120,163 subjects in the asthma medication cohort (2.0 %) [Tables 1 and 2]. Table 1 Number of subjects exposed to ADHD medications, with their number of prescribers and pharmacies visiteda Number of pharmacies 1 2 3 4 5 6 7 Total Number of prescribers  1 3,555,122 (80.