odorants are detected by olfactory receptor neurons situated within the sensillon the 3rd antennal segment and about the maxillary palps. Each receptor neuron expresses HCV protease inhibitor Fostamatinib R788 one odorant receptor genes out of pool of 60 G-protein coupled receptors. All ORNs expressing the same receptor converge, in standard, to at least one glomerulus in the antennal lobe. AL glomeruli may also be innervated by at least two communities of local interneurons, and by projection neurons. While the purpose of the LNs in the control of odor information continues to be under discussion, it’s known that PNs hold olfactory information to higher brain centers, for example the mushroom bodies and the lateral protocerebrum. To investigate the recognition qualities of the ORNs Cholangiocarcinoma and to understand how odor data is processed in the fly brain, we’ve used the process to state the calcium alarm GcAMP in different neuron populations along the olfactory pathway. We measured odor evoked calcium responses in ORNs that show the olfactory receptor Or22aiming at detailed characterization of its molecular receptive range. We screened the responses to 104 odors both at the degree of the Lymph node sensory transduction on the antennand of the transmission in the AL. At 102 dilution, 39 maximal response was elicited at least half by odors. For these odorants we recognized dose response relationships over their entire dynamic range. Ethyl hexanoate and methyl hexanoate were the best toys, eliciting consistent responses at dilutions only 109. We found no differences between the antennal and the AL MRR. Our results show that Or22has broad however selective MRR, and could be functionally defined both as generalist and specialist regarding its ecological role in odor recognition. Next, we examined scent coding at citizenry Lapatinib clinical trial level. We analyzed the representation Lonafarnib clinical trial of three smells across broad concentration range within four different neuron populations innervating the AL. ORNs were labeled by means of Gal4 line driven by the selling place of Or83b, two different LN numbers were labeled using two enhancer trap lines provided by Dr. PNs and Kei Ito were labeled utilizing an enhancer trap line created by Dr. Gertrud Heimbeck. Our datshow that, in general, greater concentrations induced increases in response amplitude and also in the amount of responding glomeruli. In most cases, the sensitivity of PNs was similar to that of ORNs, while that of the LN was shifted to higher concentrations. The dynamic range of PNs and ORNs was also broader than that of LNs. When comparing the 2 different LN subpopulations, differences in the spatial distribution of the answers in addition to differences in their temporal dynamic were found.