It is a lipophilic derivative and crosses to the brain. It modifies MES (maximal electroshock) and inhibits PTZ (pentylenetetrazole) induced clonic seizures.3 NBV is a relatively new highly cardioselective, β-adrenergic receptor antagonist not attributed to blockade of α1-adrenergic receptors selleck compound on smooth muscle cells. NBV has antioxidative effect and is a highly lipophilic drug. Patients with epilepsy may have impaired cognitive abilities and AED therapy may

contribute to this impairment. Such patients would therefore need additional treatment, beside AED therapy to correct the accompanying neurological disorder. There is no effective treatment of seizures in stroke and hence treatment needs to be initiated in the context of the patient. The presence of co morbid conditions and the use of other drugs also complicate antiepileptic therapy, and the risk of drug interactions is a particular hazard in elderly patients on multiple co medication. So, the present study was an attempt to evaluate the antiepileptic efficacy of a combination of drug with antihypertensives which can Venetoclax be effective when associated with risk factors especially cerebrovascular risk factors, stroke which might precipitate epilepsy. Male albino swiss strain mice weighing 18–30 g were procured

from the Central Animal House Facility, I.T.S Paramedical College, Ghaziabad, India (approval no – 1044/C/07/CPCSEA/27th Feb 2007). Animals were housed in groups of 5–6% and maintained at 20–30 °C and 50–55% humidity in a natural light and dark cycle, with free access to food and water. Utmost care was taken to ensure that animals were treated in the most humane and ethically acceptable manner. The drugs used were NBV (Nebicard, Torrent Pharmaceuticals, India), GBP (Gabapin, Intas Pharmaceuticals, India) and a chemoconvulsant PTZ (Sigma, USA). NBV and GBP were suspended Oxalosuccinic acid in 0.25% of carboxy methyl cellulose (CMC) in 0.9% saline solution and were freshly prepared prior to administration. All the drugs were given

in volumes of 10 ml/kg. NBV was administered at a dose of 0.25, and 0.5 mg/kg p.o.4 while gabapentin was administered at a dose of 50 and 100 mg/kg p.o.5 PTZ was administered at a dose of 70 mg/kg i.p.6 The drug treatment was given for 4 days and observations were made at the 4th day after drugs treatment. The observations were made at the time of peak effect of the drugs (for NBV after 30 min for GBP after 2 h). The control animals received 0.25% CMC in 0.9% saline solution. All the parameters were performed to all groups i.e control as well as drugs treated. The seizures threshold and the latency to seizures was evaluated by Increasing Current Electroshock Seizure test7 and PTZ test.6 Spontaneous alternation method8 and rotarod9 test was performed for the evaluation of neurobehavioural impairment. Biochemical estimation was done by measuring the level of Lipid peroxidation10 and reduced glutathione11 in brain.