Investigations in this simple organism often guide the direction of chemotaxis studies in areas such as forming concepts, discovering molecular components, revealing pathways and networks. The cooperation between experimental approaches and computational modeling has helped us
to comprehend the signaling network as a system. To further reveal the relationships among the molecular mechanisms of individual signaling steps, a continuous interplay between model development and refinement and experimental testing and verification will be useful. This article focuses on a chemoattractant G-protein-coupled receptor (GPCR)/G-protein gradient sensing machinery, which ismonitored by PIP(3) responses and investigated by the interplay between live cell imaging learn more experiments and computational modeling.
We believe that such an approach will lead to a much better understanding of GPCR-controlled chemotaxis of all eukaryotic cells. (C) 2011 John Wiley & Sons, Inc. WIREs Syst Biol Med 2011 3 717-727 DOI: 10.1002/wsbm.143″
“The effects of formulation and storage time on the physicochemical and rheological properties of a stirred yogurt, with the inclusion of a Mexican caramel jam (“cajeta”) as a flavor source, were studied. The systems were prepared by following a factorial design, analyzed after formulation and during four weeks of storage by studying three factors: fat, caramel, and x-carrageenan with different levels. Formulation as well as the storage time Selleck ARN-509 influenced in a different degree both properties: physicochemical and flow. Soluble solids and moisture were stable, pH decreased while acidity Selleck HIF inhibitor augmented; the luminosity remained constant but redness and yellowness showed an inverse
relationship as a function of storage. The non Newtonian behavior of the flavored yogurt was fitted by the Herschel and Bulkley model, in which fat increased the yield stress and consistency coefficient; both parameters increased with storage in contrary to the flow behavior index. Dynamic tests and microscopy observations completed the characterization, a weak gel was identified. (C) 2012 Elsevier Ltd. All rights reserved.”
“Background and aim of the study: The early diastolic transmitral velocity/early mitral annular diastolic velocity ratio (E/Ea) reflects left ventricular (LV) filling pressure in a variety of cardiac diseases. The value of this parameter in patients with significant mitral regurgitation (MR) remains controversial. It has been hypothesized that, by combining the index of diastolic function (E/Ea) and a parameter that explores LV systolic performance (Sa, mitral annulus peak systolic velocity), a close prediction of the LV end-diastolic pressure (LVEDP) can be provided. Hence, the study aim was to assess the relationship between a new parameter, E/(EaxSa), and LVEDP in patients with severe MR.