I loved what I would call the “structured variety” of my professional life; each day was different but the weeks had a definite balance and rhythm around research, practice, education, and administration. I divided the week into 10 half days and distributed my time in those buckets among these various responsibilities. Nevertheless, my professional identity was always that of a physician-scientist, and I was careful to assure Regorafenib solubility dmso adequate time and attention to my laboratory. In 1999, I was offered the position as Chair of the DOM at Mayo, an opportunity, quite frankly, that I never seriously aspired to, but one that I accepted with great enthusiasm and excitement. My 9 years as Chair of the DOM were

among the most satisfying of my professional life. With the help of superb vice and associate chairs, skilled administrators, and brilliant division chiefs, we developed an ambitious strategic plan for the department, doubled its size, increased NIH funding four-fold (moving our Department from 37th to 12th in NIH funding Vemurafenib molecular weight for departments of medicine) and undertook a major departmental restructuring through fusion of several existing divisions, establishment of new ones, and development of programs in aging, innovative

health care delivery, clinical immunology and immunotherapeutics, integrative medicine, global health, translational immunobiology and biodefense, and professionalism. Many of these programs have subsequently evolved into centers serving the entire Mayo enterprise. So, what have I learned from these experiences that might be of value to young colleagues? Try hard to get the right first job; I did and that is why I have never left Mayo. Make

sure your laboratory is up and running successfully before you seriously this website consider major administrative responsibilities, however seductive having a titlemight seem. Be organized in the use of your time; your ideas and your time are your most valuable assets. Be open to opportunities that you may never have aspired to, but know who you are; in my case, I am always a physician-scientist. And make sure you have fun (I think I already said that but it is worth saying again). My research program, being as objective as I can be, is thriving and remains the most satisfying component of my professional activities. We continue to develop new areas in cholangiocyte pathobiology based on the strategy that we need to understand how cholangiocytes function normally to generate hypotheses relevant to how their dysfunction might result in disease. Currently, the laboratory is heavily focused on the function and dysfunction of cholangiocyte primary cilia, an organelle that historically had been considered vestigial but more recently is recognized as critically important in development, cancer, and cystic kidney and liver disease (Fig. 3B).