Future LLIN distributions can learn from the paradigm established in this project.”
“Background: Lack of habituation during repetitive stimulation is the most consistent interictal abnormality of cortical information processing observed in migraine. Preventive migraine treatments might act by stabilizing cortical excitability level and thus the habituation to external stimuli.
Methods: We examined the effects of preventive treatment
with topiramate on migraineur’s CX-5461 ic50 habituation to nociceptive stimulation. Scalp potentials were evoked by Nd-YAP Laser stimulation of the hand dorsum and supraorbital region in 13 patients with migraine without aura (MO) and 15 healthy volunteers (HV). The exam was repeated in MO before and after treatment.
Results: We observed a lack of habituation and lower initial amplitudes in MO compared to HV. These abnormalities reached statistical PXD101 supplier significance for N1 LEPs component, generated in the secondary somatosensory cortex (SII), but not for N2/P2 complex, generated in the insula and anterior cingulated cortex (ACC). Topiramate normalized the N1 habituation pattern in MO, with a significant correlation between clinical effects and normalization of neurophysiological responses.
Conclusions: Our results indicate a modulating
action of topiramate on cortical processing of sensorial stimuli, mainly regarding the sensory-discriminative component of pain, elaborated by SII, without a significant effect on the affective dimension of pain, in which the ACC has an important role.”
“The influence of addition of nonreactive silicone oil or semianchored silicone polymer on crosslinked poly(dimethylsiloxane) (PDMS) rubber-rubber adhesion was studied. The additives can be considered either a tackifier, or connector molecules, able to cross the interface and entangle. In both cases, it influences
the tack of the elastomers. An additional variable is the molecular weight of VE-821 molecular weight the additive, which affects the reptation of the polymer chains. Polymer-polymer demixing, which is the result of thermodynamic incompatibility of mixed polymers is another factor that influences tack. It causes the free chains to appear at the surface forming a layer of oil, which actually destroys the tack of the PDMS samples. The resulting tack phenomena as a function of oil, respectively semianchored silicone polymer chains, are very much dependent on the transient nature of the polymer reptation: in many cases the polymers need very long time periods to obtain equilibrium in interphase crossing, or oil sweats out of the crosslinked polymers, forming a liquid layer between the two phases resulting in a low tack value, due to hydrodynamic wetting alone. (C) 2009 Wiley Periodicals, Inc.