col. 2009, 76, 734 744. 118. Tiedemann, R.E, Schmidt, J, Keats, J.J, Shi, C.X, Zhu, Y.X, Palmer, S.E, Mao, X, Schimmer, A.D, Stewart, A.K. Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin DNA-PK inhibition like activity and NF kappaB with antimyeloma activity in vitro and in vivo. Blood 2009, 113, 4027 4037. 119. Wu, C.C, Chan, M.L, Chen, W.Y, Tsai, C.Y, Chang, F.R, Wu, Y.C. Pristimerin induces caspase dependent apoptosis in MDA MB 231 cells via direct effects on mitochondria. Mol. Cancer Ther. 2005, 4, 1277 1285. 120. Yang, H, Landis Piwowar, K.R, Lu, D, Yuan, P, Li, L, Reddy, G.P, Yuan, X, Dou, Q.P. Pristimerin induces apoptosis by targeting the proteasome in prostate cancer cells. J. Cell Biochem. 2008, 103, 234 244. 121. Hsu, Y.L, Kuo, P.L, Chiang, L.C, Lin, C.C.
Involvement of p53, nuclear factor kappaB and Fas/Fas ligand in induction of apoptosis and cell cycle arrest by saikosaponin d in human hepatoma cell lines. Cancer Lett. 2004, 213, 213 221. 122. Leung, C.Y, Liu, L, Wong, R.N, Zeng, Y.Y, Li, M, Zhou, H. Saikosaponin d inhibits T cell activation through the modulation Streptozotocin of PKCtheta, JNK, and NF kappaB transcription factor. Biochem. Biophys. Res. Commun. 2005, 338, 1920 1927. 123. Wong, V.K, Zhou, H, Cheung, S.S, Li, T, Liu, L. Mechanistic study of saikosaponin d on suppression of murine T lymphocyte activation. J. Cell Biochem. 2009, 107, 303 315. 124. Manu, K.A, Kuttan, G. Ursolic acid induces apoptosis by activating p53 and caspase 3 gene expressions and suppressing NF kappaB mediated activation of bcl 2 in B16F 10 melanoma cells. Int.
Immunopharmacol. 2008, 8, 974 981. 125. Shishodia, S, Majumdar, S, Banerjee, S, Aggarwal, B.B. Ursolic acid inhibits nuclear factorkappaB activation induced by carcinogenic agents through suppression of IkappaBalpha kinase and p65 phosphorylation: correlation with down regulation of cyclooxygenase 2, matrix metalloproteinase 9, and cyclin D1. Cancer Res. 2003, 63, 4375 4383. 126. Achiwa, Y, Hasegawa, K, Udagawa, Y. Regulation of the phosphatidylinositol 3 kinase Akt and the mitogen activated protein kinase pathways by ursolic acid in human endometrial cancer cells. Biosci. Biotechnol. Biochem. 2007, 71, 31 37. 127. Huang, H.C, Huang, C.Y, Lin Shiau, S.Y, Lin, J.K. Ursolic acid inhibits IL 1beta or TNFalpha induced C6 glioma invasion through suppressing the association ZIP/p62 with PKC zeta and downregulating the MMP 9 expression.
Mol. Carcinog. 2009, 48, 517 531. Toxins 2010, 2 2460 128. Li, Y, Xing, D, Chen, Q, Chen, W.R. Enhancement of chemotherapeutic agent induced apoptosis by inhibition of NF kappaB using ursolic acid. Int. J. Cancer 2010, 127, 462 473. 129. Pathak, A.K, Bhutani, M, Nair, A.S, Ahn, K.S, Chakraborty, A, Kadara, H, Guha, S, Sethi, G, Aggarwal, B.B. Ursolic acid inhibits STAT3 activation pathway leading to suppression of proliferation and chemosensitization of human multiple myeloma cells. Mol. Cancer Res. 2007, 5, 943 955. 130. Shan, J.Z, Xuan, Y.Y, Zheng, S, Dong, Q, Zhang, S.Z. Ursolic acid inhibits proliferation and induces apoptosis of HT 29 colon cancer cells by inhibiting the EGFR/MAPK pathway. J. Zhejiang Univ. Sci. B 2009, 10, 668 674. 131.
Wang, X, Li, L, Wang, B, Xiang, J. Effects of ursolic acid on the proliferation and apoptosis of human ovarian cancer cells. J. Huazhong Univ. Sci. Technol. Med. Sci. 2009, 29, 761 764. 132. Zhang, Y.X, Kong, C.Z, Wang, L.H, Li, J.Y, Liu, X.K, Xu, B, Xu, C.L, Sun, Y.H. Ursolic acid overcomes Bcl 2 mediated resistance to apoptosis in prostate cancer cells involving activation of JNK induced Bcl 2 phosphorylation and degradation. J. Cell Biochem. 2010, 109, 764 773. 133. Chang, H.C, Chang, F.R, Wang, Y.C, Pan, M.R, Hung, W.C, Wu, Y.C. A bioactive withanolide Tubocapsanolide A inhibits proliferation of human l