Data obtained Pacritinib aml from the onsite testing sessions will be entered onto a scorecard as the tests are performed and scores made available. Physical activity data provided by the accelerometer will be downloaded and scored using MS-specific cut points55 to determine the amount of physical activity engagement at varying intensities. The corresponding accelerometer logs will be used to validate wear time. Data analysis The proposed data analysis will

be a 2 (FlexToBa vs Healthy Aging condition)×2 (time) mixed factor analysis of variance (ANOVA) that follows intent-to-treat principles. Missing data will be handled via multiple imputation analysis. F-statistics will be decomposed using post hoc analyses including paired and independent samples t tests with a Dunn-Bonferroni correction of α. Effect sizes for F-statistics and differences in mean scores will

be expressed as partial η2 and Cohen’s d, respectively. Ethics and dissemination Additionally, the trial was registered with ClinicalTrials.gov (NCT01993095). Prior to study involvement, all participants who meet eligibility criteria will be presented with and asked to sign an informed consent document detailing the study’s purpose, assessments and data collection, risks and benefits, privacy and rights, costs and remuneration, and contact information. The informed consent document also stresses the fact that participation in this project is entirely voluntary and that participants are free to withdraw from the study at any time without penalty. Furthermore, confidentiality is assured for all participants with regard to any personal responses and information provided throughout the trial. All data collected will be numerically coded and aggregated; therefore, no individual data will be identifiable. Results from this study will be presented at scientific meetings and published in scholarly journals. Discussion The purpose

of this randomised controlled pilot trial is to test the efficacy of a 6-month, home-based, DVD-delivered exercise programme physical function and QOL in older adults with MS. Given that this programme was found to be efficacious in a large sample of relatively healthy community-dwelling older adults,24 we hypothesise that older adults with MS who get assigned to the exercise condition will experience similar if not greater effects on the physical function. Carfilzomib Persons with MS are typically less active than their healthy counterparts and generally suffer from a higher degree functional limitations and disabilities than other older adults without chronic conditions. If participants in the exercise condition of this trial experience maintenance or improvements in physical function as a result of programme engagement, it could lead to improvements in QOL and may ultimately have a considerable impact on public health, especially for those within the MS community.