CRL at 12.0 to 12.6 weeks of estimated gestational age selleck screening library obtained during nuchal translucency screening was selected as an estimate of early fetal growth. Mean first-trimester CRL of the LGA noenates at term was compared via student’s t-test with mean first-trimester CRL of SGA neonates at term.

Results. In all, 121 neonates were included in the study. Mean first-trimester CRL of the 63 LGA-term neonates was 62.7 +/- 6.0 mm (95% confidence interval, +/- 1.49 mm; range, 61.21-64.19), while that of the 58 SGA-term neonates was smaller at 58.8 +/- 6.9 mm (95% confidence interval, +/- 1.79

mm; range, 57.01-60.59 mm). This 3.9 mm difference between the means was statistically significant (P=0.01).

Conclusion. We found that birthweights of LGA and SGA neonates at term were associated

with Fosbretabulin mw their first-trimester CRL measurements, thus, indicating that fetal growth patterns apparent early in pregnancy continue through term.”
“Objectives: To assess the associations of maternal asthma severity and control with pregnancy-induced hypertension (PIH), gestational diabetes and cesarean delivery. Methods: A cohort of 41 660 pregnancies from women with and without asthma who delivered between 1990 and 2002 was constructed by linking Quebec’s administrative databases. Maternal asthma was defined by at least one asthma diagnosis and one dispensed prescription for an asthma medication in the 2 years before

or during pregnancy. Asthma severity and control were assessed using validated indexes during the entire pregnancy to study cesarean delivery and 1-year prior to week 20 of gestation to study PIH and gestational diabetes. Generalized Estimation Equation models were used to obtain odds ratios (OR) for PIH, gestational diabetes and cesarean in association with maternal asthma severity and control. Results: Almost one-third of the women had uncontrolled asthma and up to 5% had severe asthma. Severe asthma increased the risk of cesarean delivery (OR = 1.35; 95% CI: 1.11-1.63) Selleckchem Erastin compared with mild asthma, but no association was found between asthma severity and the other outcomes. The level of asthma control was not associated with any of the outcomes, except for a nearsignificant increased risk of PIH among uncontrolled women (OR = 1.18; 95% CI: 0.97-1.42). Conclusions: The risk of gestational diabetes was not associated with asthma severity or control, and the risk of PIH was not associated with asthma severity. However, further studies are needed to clarify the association between asthma control and PIH. The increased risk of cesarean among women with severe asthma may be explained by the physician’s and patient’s concerns over the safety of normal delivery.