Biomaterials derived from artificial or organic polymeric hydrogels are finding widespread applications in bio-medical engineering, ranging from tissue repair, regenerative medicine, to drug delivery. These advantages make supramolecular hydrogels a promising alternative for polymeric hydrogels. Afatinib structure Among the molecules behave as the building blocks for supramolecular hydrogels, peptide based hydrogelators6 are usual candidates because of their scientific significance, more developed synthetic chemistry, and the capability to create a large set of diverse molecules from the small array of derivatives. There are numerous examples of peptide based functional foundations for making nanofibers and generating hydrogels. The nanofibers of peptide amphiphile compounds may display a higher density of epitopes for regulating the difference of neuron progenitor cells or leading cartilage regeneration. The hydrogels are formed by self complementary oligopeptides for cytokine release and cell culture. 11 Amino-acid functionalized when induced enzymatically hydrogel particles generate protein. A tiny peptide to conjugate with T lactam transforms into a hydrogelator from the catalysis of the T lactamase. A low molecular-weight gelator containing amino acid moieties Organism confers liquidcrystalline gels. It is important and necessary to explore new ways for creating supramolecular hydrogels as smart materials for controlled Decitabine 1069-66-5 drug release in the particular sites or areas in an organic system. Olsalazine, being a prodrug and a substrate of azo reductase, achieves colon specific drug-delivery via catalytic era of mesalazine inside the colon at the site of inflammation, since colonic microflora produces azo reductase to reduce the azo group into the corresponding amine. Particularly, we synthesized a hydrogelator with a derivative that is made up of team, two phenylalanines and one modified lysine residue holding an olsalazine moiety in the side chain. Home assembles to form a hydrogel at mildly acidic conditions. The reduced amount of olsalazine not simply leads to gel to sol phase transition, but also produces 5 aminosalicylic acid.