ApoA1 reflects antiatherogenic HDL particles and hence the ApoB:ApoA1 ratio correlates with Epigenetic inhibitor order the amount of cholesterol likely to be deposited in the arterial wall; the higher the ratio, the more atherogenesis and hence an increasing cardiovascular risk [26,32]. Several large studies conducted in the general population have shown the clinical relevance of the ApoB:ApoA1 ratio. The INTERHEART study reported that non-fasting ApoB:ApoA1 ratio was superior to any of the cholesterol ratios for estimation of the risk of acute MI in all ethnic groups, in both sexes and at all ages [29]. In the AMORIS study,

the strongest single variable that related to increased risk of fatal MI was the ApoB:ApoA1 ratio [30], while the MONICA/KORA study also found the ApoB:ApoA1 ratio to be an independent risk factor [33]. The greater increase in HDL-c and greater decrease in TC:HDL-c in patients receiving NVP compared with those on ATZ/r is supported by the findings of a number of other studies in which patients were treated with NVP [32,33]. Furthermore, a study by Franssen et al. reported that NVP increases ApoAI production,

suggesting Doramapimod order this as a mechanism that contributes to the HDL-c increases observed after the introduction of NVP-containing regimens [17]. Finally, the veterans affairs high-density lipoprotein cholesterol intervention trial (VA-HIT) study has recently shown that modest increases in HDL-c could have significant benefits in terms of the rate of cardiovascular events [34]. Although the TDF backbone may itself help to reduce cardiovascular risk, a study by Randell et al. showed that TDF did not affect insulin sensitivity and slightly reduced TC and LDL-c [35]. On examination of the data, it is apparent that Rucaparib purchase this was a result of a statistically significant improvement in TC, which was driven mainly by a reduction in LDL-c. No significant increase in HDL-c was observed in this study. In addition, a number of other studies have also

reported no effect on HDL-c with TDF use [36,37]. This information, together with data from other studies reporting an increase in HDL-c when NVP is used with other NRTI backbones [17,38], suggests that it is reasonable to assume that the statistically significant increase in HDL-c observed in the NVP arm of the ARTEN study was not a result of the TDF backbone. No increase in TG levels was seen in the NVP group during the present study, whereas there was a significant increase in the ATZ/r group. Although there has been some controversy regarding the role of TG in cardiovascular risk, the ATP III classification of the NCEP guidelines clearly state that elevated serum TG levels are associated with increased risk of coronary heart disease and are commonly associated with other lipid and nonlipid risk factors.