to the capsa Cine to bind and activate this receptor are. But despite several speculative reports subtypes of cannabinoid receptors By additionally Tzlicher cannabinoid receptor Roman met the stringent AC480 BMS-599626 criteria is pharmacologically and functionally are not yet identified. Cabral and Thomas Griffin Expert Rev Mol Med Page 3 Author manuscript, increases available in PMC 2010, the first January. PA Author Manuscript NIH-PA Author Manuscript NIH-PA Author NIH manuscript cannabinoid receptor CB1 and CB2 are signaling both in the regulation confinement of signaling cascades Lich adenylate cyclase and cAMP, mitogen activated protein kinase, and modulation of calcium levels involved intracellular R.
On the interaction of the cannabinoid receptor YEARS with his BSI-201 Uncircumcised ligands of the G protein-coupled receptor inactive GDP guanine nucleotide exchange for the active GTP and dissociates heterotrimeric G-protein in γ and subunits. To be γ subunits to the signal paths are different from those of the subunit, such as the regulation of phospholipase C isoforms and mitogen-activated to take activated protein kinase signaling network. Subunit binds to and inhibits the activity t of adenylate cyclase, whereby the synthesis of the second messenger cAMP and negative effects on downstream cAMP-dependent Independent signaling pathways.
As a reduction in cAMP production underlying mechanism in which CB1 prevents the release of neurotransmitters and preserves the integrity T of the hom Ostatischen central nervous system, a decreased production of cAMP can also be a mode on the CB2 signaling in response endocannabino maintain immunological Hom homeostasis or alternatively a function dependence of cannabinoid by exogenous factors such as 9-THC Δ superimposed st leaders immunosuppressant. R 2 TO cannabinoid receptor Effect of immune modulation of cannabinoid Exogenous resistance of the h She and cannabinoid Exogenous immunity was t shown that reducing resistance h A variety of infectious agents. The administration of 9-THC in Δ Mice has been reported that their R Ability to reduce the infection by bacterial pathogens Listeria monocytogenes and herpes simplex virus type 2 resist. Mice studies with M And guinea pigs with genital herpes have shown an increased treated Hte incidence of viral and recurrent L Emissions in animals with Δ 9 THC.
It was also that the resistance cannabinoid Of h You compromise for Legionella pneumophila, Staphylococcus albus, Treponema pallidum, Friend leukemia Mie-virus and Acanthamoeba. These collective observations reported are compatible with the cannabinoid Influence of exogenous as having properties which the activity Th of immune cells. Have, in fact, in vitro studies using human and rodent cells showed that cannabinoid The functionality of t a variety of other immune cells.Δ 9-THC and cannabinoid Synthetics CP55940 and HU, 210 has been shown that cells inhibit contactdependent cytolysis of tumor cells by macrophages and macrophages, as mediated cells.Δ 9-THC also been reported to suppress the proliferation of B and T lymphocytes in response to mitogens specific cells, remove, the cytolytic activity t of NK cells and to inhibit the activity of t to the cells to kill, the proliferation and maturation of cytotoxic T lymphocytes. In addition, it was reported that the cannabinoid Exogenous immune cell recruitment and chemotaxis to sites of infection and / or injury. Granulomatous in mouse models Sen Am Ben-encephalitis and atherosclerosis