65).30 Honkaniemi et al compared haloperidol 5 mg in 500 mL NS IV to placebo/NS (500 mL) IV.31 Pain reduction (VAS) was greater with haloperidol (−55 vs −9; P < .001), with 80% of those receiving haloperidol reporting headache relief vs 15% of those given placebo (P < .001). Side effects of haloperidol included sedation

(53%) and akathisia (53%), with 16% unwilling to take haloperidol again (chiefly because of side effects). Table 2 shows the details of the studies on the butyrophenones. Metoclopramide is a neuroleptic/anti-emetic that is known to relieve gastroparesis and facilitate analgesic absorption.32 Common side effects include fluid retention (use with caution in patients with congestive heart failure and liver disease), lowered seizure threshold, hypertension, mild sedation, and extrapyramidal effects. Six studies compared metoclopramide 10 mg IV, 10 mg IM, or 20 mg Small molecule library PR as a single agent to placebo. Three studies showed metoclopramide to be superior to placebo. Tek et al found greater headache relief at 1 hour with metoclopramide 10 mg IV vs placebo/NS IV (67% vs 19%; P = .02); 8% of those receiving metoclopramide complained of restlessness.33 Ellis et al found pain reduction (VAS) was similar for metoclopramide 10 mg IV and metoclopramide plus ibuprofen 600 mg given PO (−75 vs −50) but was greater for both treatments compared with ibuprofen alone or placebo (both −25; P < .01).34 Cete et al compared metoclopramide

10 mg IV to IMP dehydrogenase magnesium 2 g IV and to placebo/NS IV.35 Pain reduction (VAS) was similar for metoclopramide and magnesium vs placebo (−38 vs −33 vs −24), but a smaller http://www.selleckchem.com/products/AZD2281(Olaparib).html percentage of those receiving metoclopramide and magnesium required rescue medications (38% and 44% vs 65% for placebo; P = .04). Three percent of those receiving metoclopramide complained of dystonia, and 8% of those who received magnesium complained of flushing. Three studies failed to show any superiority of metoclopramide

over placebo. Coppola et al reported that metoclopramide 10 mg IV was similar to placebo/NS IV (48% vs 29%; P = .14) and inferior to prochlorperazine 10 mg IV (48% vs 82%; P = .03).5 Jones et al found that metoclopramide 10 mg IM did not decrease migraine pain (VAS) as effectively as prochlorperazine 10 mg IM when both active therapies were compared with placebo/NS IM (metoclopramide 34% vs prochlorperazine 67% vs placebo 16%, P < .01).6 Tfelt-Hansen et al compared metoclopramide 10 mg IM or 20 mg PR to placebo/NS IM or PR.36 All patients received acetaminophen 1 g PO and diazepam 5 mg PO. Metoclopramide relieved nausea in 86% (compared with 71% for placebo; P = .04) but failed to have a significant advantage over placebo in pain relief (48.5% vs 35.3%; P = .06). Friedman et al found metoclopramide 20 mg IV plus diphenhydramine 25 mg IV (dosed up to 4 times) to be superior to sumatriptan 6 mg SQ in the percentage pain-free at 2 hours (59% vs 35%, P = .04).