43 ± 6.481 years; range 60–88) with chronic atrophic gastritis confirmed by esophagogastroduodenoscopy from October 2011–July 2012. We investigated GI symptoms including postprandial fullness, epigastric pain, epigastric burning, repetitive belching, nausea, Idelalisib cell line and vomiting. The Rome III diagnostic criteria for
FGIDs identified functional dyspepsia (postprandial fullness, epigastric pain and epigastric burning), belching (repetitive belching) and nausea and vomiting disorders. Plasma ghrelin and obestatin levels were measured with a commercial ELISA kit. The results were assessed by t-tests (IBM SPSS Statistics version 18). Results: Plasma ghrelin levels were significantly lower in patients with than without belching disorder (796,414.29 ± 237,974.39 vs. 1,041,869.57 ± 46,455.24 ng/ml, p = 0.022) and plasma ghrelin/obestatin ratios were also significantly lower in patients with than without belching disorder (188,435.83 ± 67,094.04 vs. 239,243.70 ± 104,901.86, p = 0.038), but plasma obstatin levels were similar (p = 0.745). No significant differences were seen for any plasma levels for functional dyspepsia and nausea and vomiting disorders. Conclusion: Belching find more disorder was associated with decreased plasma ghrelin levels and ghrelin/obestatin ratios in elderly patients with chronic atrophic gastritis. Key Word(s): 1. ghrelin;
2. obestatin; 3. belching; 4. gastritis; Presenting Author: SUCK CHEI CHOI Additional Authors: ZOU DUOWU, MEIYUN KE, SOMCHAI LEELAKUSOLVONG, JAN TACK, EAMONN QUIGLEY, ANDY LIU, JINYONG KIM Corresponding Author: SUCK CHEI CHOI Affiliations:
Wonkwang University College of medicine; Second Military Medical University; Peking Union Medical College Hospital; Mahidol University, Bangkok, Thailand; Ku Leuven Research & Development, Waaistraat, Belgium.; The Methodist Hospital and Weill Cornell Medical College, Houston, Tx, USA; Janssen, Shanghai, China; Janssen, Asia-Pacific Objective: To assess baseline symptoms of chronic constipation (CC) and evaluate Aprepitant the effect of prucalopride in relieving these symptoms in Asian and non-Asian patients Methods: Data from 4 Phase 3, randomized, double-blind, and placebo-controlled studies were analyzed. The CC-associated symptoms: abdominal bloating, abdominal pain, hard stool, and straining were summarized at baseline for Asian and non-Asian subgroups. The effect of 12-weeks treatment with prucalopride 2-mg versus placebo in relieving these symptoms as measured by improvement in the ‘Patient Assessment of Constipation Symptoms’ sub-scores was evaluated in Asian and non-Asian patients. Change from baseline in each symptom score was analyzed using an ANCOVA model with treatment, study, and baseline spontaneous bowel movement (SBM) category as factors and baseline value for each symptom score as covariates for each race subgroup. Results: A total of 1782 patients (26.7% Asian; 73.3% non-Asian) were included in the analyses.