1 % octenidine/2 % phenoxyethanol,

is a widely used antiseptic in modern wound management. It is considered to selleck kinase inhibitor have a very low allergenic potential. Thus far, neither allergic nor irritant contact dermatitis to the product has been described.

Patients and methods: Chronic wounds in 251 patients were treated with Octenisept (R); 11 developed signs of contact dermatitis. The symptoms improved after discontinuation of the antiseptic. Eight of these patients were patch tested to the antiseptic and its components.

Results: The eight patients all showed a positive reaction to the product. In at least three cases a reaction to the components cocamidopropyl betaine and phenoxyethanol was found, but not to octenidine dihydrochloride.

Conclusions: In this cohort, more than three percent of the treated patients

developed a contact dermatitis to the antiseptic. However, the differentiation between allergic and irritant contact dermatitis towards the ingredients of the antiseptic remains problematic.”
“Several species of Senna are well known for their therapeutic properties, being used in folk medicine to treat throat inflammation and constipation. In this regard, the anti-inflammatory, laxative and intestinal motility effects of different extracts of Senna macranthera (Colladon) H. Irwin and Barneby leaves were determined. The hexane extract significantly reduced carrageenan-induced paw oedema Vorasidenib nmr in rats in a manner similar to that of sodium diclofenac. A laxative effect was observed for the methanolic and hexane extracts comparative find more to the standard drug

bisacodyl; however, only the hexane extract increased the intestinal motility in the studied period. Moreover, the extracts were evaluated for their antioxidant activity and the ethyl acetate extract presented a pronounced activity comparable to the standard rutin. Phytochemical screening was also performed and phenolic compounds like flavonoids, tannins and coumarins were observed in all extracts except for the hexane extract, which instead presented anthrones, triterpenes and steroids in its composition. The HPLC profile showed the presence of the anthraquinone emodine in all tested extracts.”
“Persistent parvovirus B19 (PVB) infection has been reported sporadically in immunocompromised patients including hematopoietic stem cell and solid organ transplant recipients. However, the pathogenesis of persistent infection has yet to be fully elucidated. We report here a patient with multiple myeloma developing red cell aplasia during the hematopoietic recovery after allogeneic hematopoietic stem cell transplantation (HSCT) caused by PVB. The patient had already had PVB viremia before transplantation and remained asymptomatic. The route of PVB transmission was considered to be direct contact with the patient’s family member with primary PVB infection 1month before transplantation. Treatment with intravenous immunoglobulin resulted in prompt resolution of anemia.