Brivanib alaninate BMS-582664 nd ZM447439 on growth arrest and polyploidy

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ZM447439, a novel aurora kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells. Blood . 2006, 108 abstr 1990. 86. Georgieva I, Koychev D, Wang Y, et al. ZM447439, a novel promising aurora kinase inhibitor, provokes antiproliferative and proapoptotic effects alone and in combination with bio and chemotherapeutic agents in gastroenteropancreatic neuroendocrine tumor cell lines. Neuroendocrinology. 2010, 91:121 30. 87. Vidarsdottir L, Bodvarsdottir S, Ogmundsdottir H, Eyfjord J. Targeting aurora kinases in BRCA2 mutated breast cell lines. Proc Am Assoc Cancer Res. 2008, 49 abstr 2395. 88. Crispi S, Fagliarone C, Biroccio A, et al. Antiproliferative effect of aurora kinase targeting in mesothelioma. Lung Cancer. 2010 article in press. 10.1016/j.lungcan.2010.03.2005 Green et al.
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