In contrast, ABCG2 efflux compounds in MP-470 the placenta from the F Status and localized plays an r Barrier in the fetal to maternal. Researchers have a variety of compounds, such as 2 amino phenylimidazopyridine one methyl-6, 2 3 methylimidazoquinoline amino and riboflavin, the reports by ABCG2 in breast milk. There have been many recent reviews, the pharmacokinetics to the clinical importance of ABC transporters in drug development. In the following sections, we summarize the strategies that are used by researchers in the fight against MDR in cancer therapy. RE sensitizing cancer cells, cancer drugs multiresistant DEVELOPMENT OF INHIBITORS ABC drug transporters Ideally, the most direct and easiest way to restore drug sensitivity caused cancer cells by MDR ABC transporters of drugs is, the outflow block Wirkstofftr hunter mediation.
Since 1980, researchers have searched both broad spectrum and specific modulators that can reverse MDR in cancer cells. Enormous efforts have been made to discover, and to synthesize Ecdysone these modulators inhibitors. Several examples of ABC transporter inhibitors drugs were discovered or synthesized are listed in Table 1. In addition, alternative strategies such as the regulation of the expression of transporters or medication that is targeted drug transporters also sp Ter discussed. Design or research chemosensitization m Chtig are selective, low inh Pension toxicity t Highly effective and was more difficult than expected.
However, the fa To set up drug resistance using the available pharmacological and structural information auszuw choose Or design new inhibitors is now much clearer. It is in principle Tzlich agreed that chemosensitizer inhibitor should erh hen able to restore intracellular Mirror temperatures between anticancer drugs to drug sensitivity And st Acids or Photoaffinit Tsmarkierung one Arzneistofftr Gers in particular. The first was chemosensitizer ABCB1. 1981 by Tsuruo et al if the calcium channel blocker verapamil has been found again, vincristine-resistant P388 leukemia miezellen sensitize vincristine and vinblastine. Another study provided direct evidence that verapamil vinca alkaloids for toxicity t Increase by an increase Accumulation in the resistant cells restored. However, it was the high concentration of verapamil bearable Glicher to improve the efficiency of vinblastine conducted in a Phase I study in 1985.
Sp a couple of years Ter, the immunosuppressant cyclosporin A has been shown to completely Awareness recreate a resistant variant of human acute T-cell line lymphoblastic leukemia mie Cell vincristine and daunorubicin. Zus Tzlich CsA was also effective. Against resistance to doxorubicin in solid tumors It was then used as a reference for ABCB1 inhibitors for in vitro studies due to its high performance and low inh Pension toxicity Used t. Unfortunately, such as verapamil obtained in clinical trials not CsA clinical ABCB1 inhibition at the concentrations tested. Latest