We examined the prognostic value of the number of positive LNs, number of LNs removed, and LN ratio (LNR) in order to determine the influence of an adequate LAD on overall survival (OS).
We analyzed data of 316 patients with AEG treated in our institution (2001-2011) regarding clinicopathological data, treatment, morbidity, mortality, and long-term prognosis. Univariate and multivariate analysis was performed using Cox regression to evaluate the prognostic
impact of(y)pN category, number of LNs removed and LNR.
OS decreased with higher count of positive LNs (p < 0.001) and higher LNR (p < 0.001). Whether > 6, > 15, or > 30 LNs were removed did not influence OS, neither in the entire study population nor within individual (y)pT or (y)pN categories. Multivariate analysis MEK inhibitor revealed LNR (p < 0.001) besides M category (p = 0.015) and tracheotomy during the postoperative course (p = 0.005) as independent predictors of OS.
The classification
according to the number of involved LNs in the latest edition of the UICC staging system improves prognostication in patients with AEG. The importance of an adequate LAD is shown by the high prognostic relevance of the LNR rather than the absolute number of LNs removed.”
“The genus Baccharis L. belongs check details to Asteraceae and comprises several medicinal species. Both Baccharis spicata (Lam.) Baill. and Baccharis curitybensis Heering ex Malme are traditionally known as “”vassoura”" (broom) in Brazil. The species B. spicata has antibacterial, antioxidant and C188-9 nmr trypanocidal activities. Despite of B. curitybensis shows an external morphology quite similar to B.
spicata, no chemical and pharmacological study is available about B. curitybensis. Therefore some confusion and/or problems can occur during popular use. In order to differentiate these taxa, the morpho-anatomy of their leaves and stems were investigated according to the usual light and scanning electron microtechniques. The species B. curitybensis reveals smooth and revolute margin, alternate leaf arrangement and non-capitate uniseriate glandular trichomes. Otherwise, dentate and flat margin, opposite leaf arrangement and uniseriate flagelliform non-glandular trichomes are observed in B. spicata. Morphological and anatomical data can be useful for differentiating B. curitybensis and B. spicata.”
“Accurate preoperative radiological staging of hilar cholangiocarcinoma remains difficult, and a number of patients are found to have irresectable advanced tumours or occult metastases at exploration. Staging laparoscopy can improve the detection of irresectable disease, avoiding unnecessary laparotomy. This study examines the role of staging laparoscopy in hilar cholangiocarcinoma, with a focus on yield over different time periods and identification of preoperative factors increasing the risk of irresectable disease.