Calcium channel blockers not increased HTES risk in humans showed teratogenic, although studies of high doses of calcium channel blockers administered tr Chtigen rats and rabbits showed a increased Hte Pr Prevalence of cardiovascular and skeletal malformations S 11 18 Among the beta-blockers were intrauterine growth retardation bradycardia and hypoglycaemia Chemistry in a number of studies that have evaluated their use for the treatment of high blood pressure w During pregnancy19, found the 20th However, a number of other studies have Tosedostat CHR2797 not increased HTES risk of these results shows, and beta blockers together as a class to be safe for the development of the fetus, especially in terms of their positive impact on maternal health w During the pregnancy .4, 21 Although the use of kardiovaskul Ren drug is widely used in pregnancy depth data published on its safety profile for f Tale development remains relatively rare. We have recently completed a study ver Ffentlicht, a cohort of more than 100,000 births from 1996 to 2000 in five large en health organizations to assess the safety of selective inhibitors of serotonin reuptake inhibitors and tricyclic antidepressants used pregnancy22.
To ensure the security of the h Most common used cardiovascular drugs w To during pregnancy are ready, we have this database is based on the same study, Bev POPULATION the risk of perinatal complications and congenital anomalies in children in utero exposed to beta- blockers and calcium channel blockers. This study was conducted as part of the HMO Research Center for BMS-354825 Education and Research on the therapeutic program. Since this study is the design the same as before on the use of antidepressants w During reported pregnancy22 is only a summary of methods will be presented here. The CERT program is an initiative of the AHRQ national awareness about the benefits and risks of therapeutic education and funded research23.
Five integrated health care CERT HMO, with a total population POPULATION of more than 3 million members, participated in this study. Group cooperation in health, Harvard Pilgrim Health Care, Henry Ford Health System, Kaiser Permanente Colorado, Kaiser Permanente Northwest Health Pl Ne serve different Bev Lkerungsgruppen, with African-American members percent from 2% to 24%, the proportion of Hispanics from 1% to 16%, and the percentage of Asian Americans from 1% to 5% of the health plan membership. Each HMO Institutional Review Board approved this study.
Study Design This retrospective study was conducted using electronic databases of health care information on the member registration, outpatient drug distribution and the station re Contains and outpatient diagnoses and procedures Lt We have the female members of more than 15 years, the h a community or HMO Capital PUBLIC between 1st January 1996 and 31 December 2000 were authorized identified, for the birth of a child and the attire Rt in coverage of prescription drugs have to be registered for at least one year prior to admission. The mother-child bond was performed using unique identifiers that were used for epidemiological studies of mother and child pairs in these health systems. We Descr Nken our study to the children, which is a follow-up of 365 days for the evaluation of congenital anomalies or 30 days, to evaluate newborns ben CONFIRMS had. A total of 99,419 pregnancies in the five HMO participants 87,407 children were at least 30 days follow-up, joined a matching rate of 88%.