And Laird. In the absence GSK-3 alpha inhibitor of statistically significant heterogeneity t pr presents the results With the model with fixed effects. CochranQ statistic was used to the heterogenite t and I2 analysis quantify the Ausma variation due to heterogeneity of the t t pleased to recognize the good fortune. A value below 25% is arbitrary weight Hlt to a low level of heterogeneity to represent t. Metaregressions were carried out to m Possible sources of any observed heterogeneity T in exploring treatment effect of constipation. Potentially variable lengths zusammenh about security Has been included in univariate fashion, in separate models to assess their contribution to heterogeneity t. Publication bias was assessed visually using funnel plots the size E to study in comparison, the proposed use of the treatment effect for each item set.We tests for asymmetry by Egger and Begg, to determine whether the degree of distortion Ver Ffentlichung was statistically significant. Our original intention was to characterize the overall effect of anticholinergics as a class, as compared to t liked a drug. Due to the high degree of heterogeneity t of data within the entire sample, we performed subgroup analysis individual agents. We used Stata / MP version 11.0 with  Routines to perform the analyzes. Forest plots were constructed in Stata / MP and annotated with functions of first instance in Adobe Illustrator. Results Search results and study selection Sixty eligible studies identified from the Cochrane database. The Medline search strategy identified 2022 citations more. In addition, 11 reports were identified by searching the FDA website. After reviewing the abstracts and summaries of these publications, a total of 102 reports were as f Rderf compatibility available placebo-controlled study called POSE for this meta-analysis. A total of 65 studies were excluded from the application of the exclusion criteria. Test characteristics and patient Siebenunddrei Ig studies were closing Lich included in the analysis, involving a total of 19.434 subjects. Also attempts to placebo and active treatment, including normal Ten tolterodine, darifenacin, six, three fesoterodine, oxybutynin seven, four and seven treatment groups trospium solifenacin. Twenty-five communities were conducted in a country, and 12 were carried out at the national cross. Five studies were performed in a unique research facility, and 32 carried out Studies were conducted using a multi-center design, with the number of sites in the range of 5 to 180 institutions. The average age of patients in the studies was 49-89 years, with the proportion of women ranges from 50% to 100%. Study duration ranged from 2 to 16 weeks and a total sample size of the study were as low as 48 and as high as 1481st Based quality t the first instance in relation to the quality of t on the Jadad score of the publication, all studies were randomized and controlled Strips, and there were three studies that used a crossover design. Twenty-six of these studies are not YOUR BIDDING describe the randomization technique, what of poor quality score to a t. Patch methods are described in detail in Figure 15. Methods for assessing the side effects confinement Lich constipation, were either poorly defined or lose on spontaneous reports in 34 studies. Two studies have developed the use of a questionnaire to assess unwanted described reactivation.