Table 1 Gastroenteritis, overseas travel and antibiotic use associations with IBS and FD. Data are prevalence with odds ratio and p-value below Antecedents Controls IBS alone FD alone IBS/FD overlap Overall p Sudden onset of symptoms 18.9% 34.7% 30.3% 23.5% 0.01 1.0 2.28 (p = 0.002) 1.87 (p = 0.1) 1.3 (p = 0.4) Gastroenteritis past year 8.2% 21.1% 6.1% 19.2% 0.001 1.0 2.98

selleck chemicals (p = 0.001) 0.72 (p = 0.6) 2.66 (p = 0.01) Overseas travel 6.4% 7.7% 2.9% 1.9% 0.4 1.0 1.22 (p = 0.7) 0.44 (p = 0.4) 0.28 (p = 0.2) Antibiotic use 5.7% 6.6% 8.8% 11.8% 0.4 1.0 1.17 (p = 0.8) 1.60 (p = 0.4) 2.21 (p = 0.1) Conclusions: Our population based data are consistent with patient studies CX-5461 research buy that indicate that there is a subgroup of about one fifth of people with IBS who have post infectious IBS with the onset of symptoms associated with a prior bout of acute gastroenteritis, although onset of stomach and bowel disturbance only followed gastroenteritis in 6% of FD patients and 8% of

controls. A BIRTLES,1 A SWINBOURNE,1 G MAHY,2 F QUIRK1 1James Cook University, Townsville, Australia, 2Department of Gastroenterology and Endoscopy, The Townsville Hospital, Townsville, Australia Objective/background: Patients with Irritable Bowel Syndrome (IBS) comprise a heterogeneous population making determinations about treatment provision difficult. Efforts to classify patients to specifically guide treatment

strategies have been limited. Cognitive behavioural therapy (CBT) has been previously explored. Self-administered novel web-based interventions are predicted to appeal to this group but have not been previously trialled. Patients coping with mild-moderate symptoms are predicted to benefit most; contrary to previous strategies where psychological intervention was invoked only for the group experiencing severe symptoms. Here we report the treatment response of coping-stratified groups of IBS patients to a novel, computerised self-administered CBT intervention. Methods: Specialist and community patients with click here IBS fulfilling Rome criteria (Rome III) completed a questionnaire battery assessing patient coping and gastrointestinal symptom severity. Responses were cluster analysed. Patients were classified by psychosocial characteristics. Participants were then randomly assigned to either an intervention or wait-list condition. The intervention was an easily home accessible, self-administered, web-based computerised cognitive behavioural therapy (CCBT) resource. The intervention group (n = 45) was given access to the CCBT resource for eight weeks and wait-list group(n = 32) completed a six week wait. The participants completed post-questionnaires (78% completion rate). The response to intervention was assessed in order to establish whether treatment response was predicted by classification.